This study aimed to assess the water quality of certain lakes (Bogdaproste, Trei Ozere and Radacinos) belonging to the Danube Delta, Romania. Deltaic ecosystems are subject to natural and man-made environmental stressors. If in the past these ecosystems were largely threatened by eutrophication and organic/inorganic pollution, nowadays, we must focus on hydro morphological impact. This refers to the physical character and water content of the aquatic environment, impoundment (dams and flood gate), channelization and embankments, as well as clog/siltation of lakes. Environmental parameters are those physical, chemical and biological indicators used to characterize a freshwater body, and, which vary in time and space. In this regard, 44 water samples were collected in the dry season from the three lakes, for analysis of physical-chemical quality indicators. A series of physical (T, EC, TDS, turbidity, TSS, transparency) and chemical parameters (pH, DO, nutrients, SiO2, TOC, SO42-, ORP, technophilic elements) were considered. The results obtained in the physical-chemical analyses revealed that the majority of parameters were found in line with enforcing environmental regulations. Despite that, P-PO43- and Cd concentration results of some samples were found above certain permissible limits set by the normative. Probably, these inadvertences can be associated with local conditions of the transitional deltaic environment. Further analysis is required conducting repeated measurements with the same question, meaning a routine monitoring, especially P-PO43- and Cd. Finally, it was concluded that the results of this study showed a good quality of water in investigated lakes that did not pose potential health and environmental problems related to the biota.